Panther software protein

Data Version. Click for additional info. Newsletter subscription. Enter your Email:. Please refer to our article in Nature Protocols for detailed instructions on how to use this page. Help Tips Steps:. Upload IDs: File format. Please login to be able to select lists from your workspace. Phylogenetic trees of gene families form the basis for PANTHER and these trees are annotated with ontology terms describing the evolution of gene function from ancestral to modern day genes.

One of the main applications of PANTHER is in accurate prediction of the functions of uncharacterized genes, based on their evolutionary relationships to genes with functions known from experiment.

It also includes software tools for analyzing genomic data relative to known and inferred gene functions. Multiple sequence alignments and phylogenetic trees, including curator-assigned information, are available for each family. The current version of the PANTHER database includes training sequences from all organisms in the GenBank non-redundant protein database, and the HMMs have been used to classify gene products across the entire genomes of human, and Drosophila melanogaster.

The ontology terms and protein families and subfamilies, as well as Drosophila gene c;assifications, can be browsed and searched for free.

Due to outstanding contractual obligations, access to human gene classifications and to protein family trees and multiple sequence alignments will temporarily require a nominal registration fee. In the genomic era, one of the fundamental goals is to characterize the function of proteins on a large scale. Functional divergence within the family is represented by dividing the tree into subtrees based on shared function, and by subtree HMMs.

First, we report the size and sequence diversity of the families and subfamilies, characterizing the relationship between sequence divergence and functional divergence across a wide range of protein families. Third, we use the family HMMs to rank missense single nucleotide polymorphisms SNPs , on a database-wide scale, according to their likelihood of affecting protein function.

Database Commons a catalog of biological databases. Home Database. Real time : Checking Animal Bacteria Fungi Plant Virus. Phylogeny and homology. Homo sapiens Zea mays Mus musculus. PANTHER in modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees.

PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification. Community reviews.

Word cloud. Tags Protein. Evolutionary Relationships. Related Databases UniProt. Record metadata Created on: